2024 Sox4 chip

Sox4 chip

Author: bcay

August undefined, 2024

Web14. apr 2024 · Gastric cancer. LINC00511 has been shown to promote progression of gstaric acnecr through regulating SOX4 expression and epigenetically suppressing PTEN to induce activity of PI3K/AKT pathway (Wang et al., 2024).Moreover, LINC00511 can promote growth of gastric tumors through acting as a molecular sponge for miR-124-3p and regulating … Web17. jún 2024 · SOX4 served as an oncogene and reversed the effects of METTL14 in CRC. a. The SOX4 knockdown efficiency was proved at the protein levels in HCT116 and HCT8 …

SOX4 promotes beige adipocyte-mediated adaptive …

Web25. feb 2016 · 健康所博士研究生周宸琳等人和同济大学博士后杨晓勤在健康所研究员金颖和同济大学教授张勇的带领和指导下开展合作研究，通过 ChIP-seq、 RNA-seq 和蛋白质谱等手段，全面比较分析了 SOX2 在 hESCs 和 hNPCs 中的转录调控网络和蛋白质相互作用网络。 Web1. dec 2024 · SOX4 has also been reported to regulate gliogenesis, as prolonged expression of a SOX4 transgene under the control of the human GFAP promoter activating transgene … cebu which country

Identification of SOX4 target genes using phylogenetic …

Web15. jan 2009 · SOX4 is up-regulated by TGFβ-1 treatment , and we found SMAD4 sites are significantly enriched in the SOX4 ChIP-chip peaks , suggesting that SOX4 affects key … WebFig. 6. SOX4 is targeted by miR-507, miR-557, miR-579-3p and miR-1287-5p. (A-D) The binding between SOX4 and these 4 microRNAs was verified by luciferase reporter assay. (E-H) After transfection with mimics or inhibitor of these 4 microRNAs, the level of SOX4 was detected by qPCR. (I-L) The level of SOX4 in NSCLC cells was determined by western ... WebEach SOX4 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our SOX4 Antibodies can be used in a variety of model species: Human. Use the list below to choose the SOX4 Antibody which is most appropriate for your research; you can click on each one to view full technical details ... butterfly resin moulds

(PDF) Overactive STAT3 Drives Accumulation of Disease …

Integrin αvβ6 – TGFβ – SOX4 Pathway Drives Immune Evasion in …

Web28. mar 2024 · a ChIP assay showed that SNF2L, BPTF and RBBP4 were enriched on SOX4 promoter. b ChIP assay showed that circ-DONSON silencing attenuated the enrichment of SNF2L, BPTF and RBBP4 on SOX4 promoter. c DNA-FISH verified that circ-DONSON silencing abrogated the colocalization between SNF2L and SOX4 promoter in BGC-823 … Web3. dec 2024 · Genes with a SOX4-binding site within 20 kb of a TSS in MDA-MB-231 cells are annotated in red (C) Normalized ChIP-seq tracks for SOX4, H3K27me3, H3K4me3, POL2, and H3K27ac surrounding the EDN1 locus in HMLE-S4 cells. For histone marks and POL2 both DOX-treated and -untreated profiles are represented (-/+). cebu which regionWeb16. máj 2024 · In order to determine whether SOX4 binds to the promoter of p65, a CHIP-PCR assay was performed. Our data revealed that SOX4 was able to bind to the p65 promoter at positions +15 to −104, −1490 to −1603, −221 to −318 and −831 to −931 bp. However, the CHIP-PCR assay only indicated that there was a connection between SOX4 … butterfly resin molds

"WebSOX4 is a transcription factor with pleiotropic functions required for different developmental processes, such as corticogenesis. As with all SOX proteins, it contains a conserved high mobility group (HMG) and exerts its function via interaction with other transcription factors, such as POU3F2. Recently, pathogenic SOX4 variants have been identified in several … " - Sox4 chip

Sox4 chip

SOX4 and RELA Function as Transcriptional Partners to Regulate …

Web3. máj 2011 · Tbx3, SOX4, and SOX2 ChIP data, identify a region in intron 1 of Gja1 bound by all tree proteins and subsequent ChIP experiments verify that this sequence is bound, in vivo, in the developing heart. In a luciferase reporter assay, this element displays a synergistic antagonistic response to co-transfection of Tbx3 and Sox4 and in vivo, in ... Web27. jan 2024 · Midbrain dopaminergic neurons (mDANs) control voluntary movement, cognition, and reward behavior under physiological conditions and are implicated in human diseases such as Parkinson’s disease (PD). Many transcription factors (TFs) controlling human mDAN differentiation during development have been described, but much of the …

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Web9. apr 2024 · ChIP–western blot analysis demonstrating equivalent levels of SMARCA4 protein pulldown in cells treated with either siRNA targeting SOX4 or control siRNA in … WebIn this study, we performed the luciferase reporter assay and found that SOX4 (SRY-related HMG-box 4), an inducer of epithelial–mesenchymal transition (EMT), is a transcriptional activator for the ADAM28 gene. This activation required the SOX4-binding consensus sequence at the 5’-untranslated region of the mouse and human ADAM28 genes.

WebCHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... WebLee H et al. TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer. Cancer Res 76:4994-5005 (2016). PubMed: 27328729; Mehta A …

Web22. jan 2024 · Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a proteome-wide level, has remained elusive. WebATAC-seq, ChIP-qPCR, and dual-luciferase reporter assays were carried out to verify the role of SOX4/EZH2 in the modulation of METTL3 expression upon TMZ treatment. We demonstrated that TMZ treatment upregulated the expression of the m6 A methyltransferase METTL3, thereby increasing m6 A modification of histone modification …

Web27. sep 2024 · Notably, SOX4 is a direct target gene of C-MYC; C-MYC activates SOX4 expression via binding to its promoter. In addition, Co-IP analysis demonstrated a physical …

WebIn order to explore the expression of Sox4 in WT tumor, we searched relevant chips through GEO database and found that Sox4 was highly expressed in WT tumor tissue in GSE66405 (See Figure 6C). For further determining the expression of Sox4 in WT children, ... cebu wildlifeWeb此外，体外腺病毒介导的sox4过表达在人脐静脉内皮细胞(huvecs)和人主动脉内皮细胞(haecs)中产生了相似的结果。另一方面，sox4的过表达造成了内皮细胞的形态改变以及功能损伤。上述结果提示，sox4具有促动脉粥样硬化的作用，且与sox4介导的endomt有关。 cebu white sand beachhttp://thebrain.bwh.harvard.edu/pubs/Scharer-SOX4.pdf butterfly residenceWeb1. jan 2024 · Chromatin immunoprecipitation (ChIP) experiments in human BT549 TNBC cells with a SOX4 versus control IgG antibody identified SOX4 specific peaks in the regulatory regions of interferon pathway genes (such as IRF7 and ISG15) and MHC-I pathway genes (including TAP1, TAP2, PSMB9, HLA-B and HLA-C) (Fig. 6F, Table S2). … cebu wine cellarWebAs shown in Fig. 5a, our Chip-seq data shows that the same region of Gja1 in intron 1 as found in the SOX2 and SOX4 ChIP experiments is also bound by Tbx3, implicating that it may be a conserved ... butterfly reserve texasWeb13. máj 2024 · The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular … butterfly reserves in usaWeb2. aug 2024 · SOX4 gene expression correlates with advanced cancer stages and poor survival rate in bladder cancer, supporting a potential role as a regulator of the bladder CSC properties. SOX4 might serve as a biomarker of the aggressive phenotype, also underlying progression from NMIBC to MIBC. The amplicon in chromosome 6 contains SOX4 and … cebu what to do and see