Web03/08/2024. In a phase 1/2 trial, sotorasib demonstrated acceptable safety and anticancer activity for patients with advanced pancreatic cancer and KRAS mutation who had received prior treatment. In the CodeBreaK 100 trial, 38 patients with KRAS p.G12C-mutated pancreatic cancer who had previously received ≥1 systemic therapy were enrolled. WebDec 21, 2024 · A phase 1/2 trial has shown that inhibitor sotorasib produced a confirmed objective response in 21% of pretreated metastatic pancreatic cancer patients with the specific KRAS mutation (28 ...
Sotorasib in KRAS p.G12C–Mutated Advanced …
WebSotorasib is the first small molecule inhibitor against KRAS G12C mutations and was approved by the FDA for the treatment of non-small cell lung cancer (NSCLC) in 2024. Studies have reported that it can effectively inhibit various cell lines that carry KRAS G12C mutations, including PDAC cell lines . According to the recently disclosed ... WebApr 1, 2024 · Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer The KRASG12C inhibitor sotorasib was associated with a 21.1% objective response rate and an 84.2% … texmo 3 phase 3hp submersible pump price
Sotorasib in KRAS p.G12C-Mutated Advanced …
WebSep 9, 2024 · KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal WebApr 1, 2024 · Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer The KRASG12C inhibitor sotorasib was associated with a 21.1% objective response rate and an 84.2% disease control rate among patients who had already received at least one therapy for pancreatic ductal adenocarcinoma. These data come from the phase I/II CodeBreaK100 … WebJan 5, 2024 · Background: KRAS p.G12C mutation occurs in approximately 1 to 2% of pancreatic cancers. The safety and efficacy of sotorasib, a KRAS G12C inhibitor, in … swordfish mk1