Firre lncrna
WebObjectivesThe role of lncRNAs in gallbladder cancer (GBC) remains poorly understood. In this study, we explored the function of functional intergenic repeating RNA element … WebMar 19, 2024 · The lncRNA FIRRE has been reported to anchor the inactive X chromosome to the nucleolus by binding CTCF and maintaining H3K27me3 methylation [10]. …
Firre lncrna
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WebAug 11, 2024 · Based on the mechanisms of action, the interactions of lncRNAs and hnRNPs are categorized into four groups: (1) lncRNA interacts with hnRNP to induce gene expression; (2) lncRNA interacts with hnRNP to restrain gene expression; (3) lncRNA and hnRNP interaction controls mRNA stability and translation; and (4) lncRNA and hnRNP … WebNov 26, 2024 · b lncRNA Firre is a trans-acting RNA that functions in haematopoiesis. The Firre deletion mouse was generated by inserting LoxP sites flanking the Firre gene body, including its promoter ...
WebRecently, a lncRNA, termed Firre, was identified as essential for adipocyte differentiation, and it displays a unique function in nuclear organization (136, 152, 153). Genetic deletion studies of Firre in embryonic stem cells showed that the lncRNA interacts with hnRNPU and mediates cross-chromosomal contacts between five chromosomes . WebSep 12, 2014 · It had long been suspected that RNA itself might be a key organizing factor that shapes this dynamic nuclear floor plan ( 1 ), with recent research pointing to a role for nuclear-retained long noncoding RNAs (lncRNAs) in organizing nuclear architecture. Here we provide a perspective on the classical and newly emerging role of RNA in this process.
WebThis invention relates generally to delivery of circular polyribonucleotides and compositions thereof. WebMar 29, 2024 · LncRNA FIRRE promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the expression of PXN through interacting with MBNL3. LncRNA FIRRE functions as a tumor promoter by interaction with PTBP1 to stabilize BECN1 mRNA and facilitate autophagy. FIRRE is transcriptionally activated by MYC. RMST and FIRRE, …
WebThe FIRRE lncRNA has been reported to be involved in multiple processes including adipogenesis, nuclear architecture, haematopoiesis as well as in NDDs [5,17,21,22]. The …
WebNov 5, 2024 · Long non-coding RNAs are novel regulators in neuropathic pain. In this study, we aimed to explore the role and the mechanism of lncRNA FIRRE in regulating the secretion of microglial cells-derived proinflammatory cytokines in neuropathic pain. The female mouse model of neuropathic pain was established by bilateral chronic constriction … convert from mmhg to atmWebJan 26, 2014 · Here, we identify a long intergenic noncoding RNA (lincRNA), termed functional intergenic repeating RNA element (Firre), that localizes across a 5-Mb domain around its site of transcription. This... fall potluck casserole with turkey and squashWebTuberculosis is a worldwide contagion caused by Mycobacterium tuberculosis (MTB). MTB is characterized by intracellular parasitism and is semi-dormant inside host cells. The persistent inflammation caused by MTB can form a granuloma in lesion regions and intensify the latency of bacteria. In recent years, several studies have proven that long non-coding … convert from mmhg to kpaWebFirre is a strictly nuclear lncRNA that interacts with the nuclear matrix protein hnRNPU, through a 156 bp repeat motif in its mature transcript sequence. This conserved and unique repeat motif, Repeating RNA Domain (RRD), is not only necessary to localize Firre around its site of transcription in the nucleus but also sufficient to act as a ... convert from mm to feetWebHere we show that the syntenically conserved lncRNA Firre displays distinct expression and localization patterns in human and mouse. Single molecule RNA FISH reveals that … fall potluck dinner ideasWebFeb 2, 2024 · Firre intergenic repeating RNA element (FIRRE), a lncRNA located in the nucleus, was overexpressed in colorectal cancer (CRC). However, the detailed … fall potluck themes for workFirre (functional intergenic repeating RNA element) is a long non-coding RNA located on chromosome X. It is retained in the nucleus via interaction with the nuclear matrix factor hnRNPU. It mediates trans-chromosomal interactions and anchors the inactive X chromosome to the nucleolus. It plays a role in pluripotency and adipogenesis. fall potluck ideas easy