TīmeklisEZH2 and other PRC2 components are required for hematopoietic stem cell function and lymphocyte development, at least in part by repressing cell cycle inhibitors. At … Tīmeklis2024. gada 1. febr. · Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. ... EZH2 Represses the B Cell Transcriptional Program and … National Center for Biotechnology Information
Selective EZH2 inhibitor zld1039 alleviates inflammation in …
TīmeklisM. Guo et al., EZH2 represses the B cell transcriptional program and regulates antibody-secreting cell metabolism and antibody production. J. Immunol. 200, 1039–1052 (2024). Crossref. PubMed. Google Scholar. 45. J. Yin et al., Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase … TīmeklisPirms 2 dienām · Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway ... Renal Handling and Red Cell Uptake of Cisplatin and CBDCA in Animals; Experimental cyclosporin A nephrotoxicity. status of lviv
The RNA interactome in the Hallmarks of Cancer - Gabryelska
Tīmeklis2012. gada 1. apr. · Conversely, overexpression of Ezh2 has also been implicated in the progression of various types of human cancers (Sauvageau and Sauvageau 2010; Margueron and Reinberg 2011), and a recurrent EZH2 mutation identified in B-cell lymphomas (Morin et al. 2010) was proposed to act as a dominant, cancer-promoting … Tīmeklis2024. gada 26. marts · Gain-of-function mutations in EZH2 are frequently observed in B-cell lymphoma, implying disease-dependent effects of individual mutations. Deletion … TīmeklisGut 3. November 2016. Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most aggressive malignancies with a 5-year survival rate of <7%. Due to growing incidence, late diagnosis and insufficient treatment options, PDAC is predicted to soon become one of the leading causes of cancer-related death. status of magnolia network